About Hoxa
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Current Members of the Lab

From left to right: Brennica Marlow, Davide Provasi, Abhijeet Kapoor, Kristen Marino, Marta Filizola, Sebastian Schneider, Paola Bisignano, and Yi Shang.


Located in New York City

View of Central Park from Marta's office on the 16th floor of the Icahn Medical Institute at Mount Sinai


Research Towards Non-Addictive Painkillers

We are using newly available structural information of opioid receptors in computer simulations to discover novel painkillers with reduced abuse liability and other adverse effects.

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Development of Novel, Pure Antagonists of Beta3 Integrins

We use information from structure and molecular dynamics simulations to discover novel therapeutics to treat renal, hematologic, neoplastic, bone, and/or fibrotic diseases.


Understanding How Membrane Proteins Mediate Cellular Functions

We are running massive computer simulations to find out how membrane protein complexes process cell signaling so that we can make drugs more specific and design more efficient medicines.

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We belong to the Department of Structural and Chemical Biology at the Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
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Latest Article

Preferred Supramolecular Organization and Dimer Interfaces of Op

We conducted extensive coarse-grained molecular dynamics simulations of different combinations of the three major opioid receptor subtypes in an ...

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Latest Article


We contributed to the rationalization of structure-activity relationships of the first described positive allosteric modulators of the δ-opioid ....

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Latest Article


We review here recent studies that have used the crystal structures of opioid receptors as a basis for revealing mechanistic details of signal ......

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July 2015
Congrats to Yi on the birth of her beautiful baby girl
March 2015
Kristen Marino joins the lab
February 2015
Abhijeet Kapoor joins the lab
January 2015
Well over 11K chapter downloads for Marta's book