From left to right: Brennica Marlow, Davide Provasi, Abhijeet Kapoor, Kristen Marino, Marta Filizola, Sebastian Schneider, Paola Bisignano, and Yi Shang. Photograph courtesy of Yi Shang.
View of Central Park from Marta's office on the 16th floor of the Icahn Medical Institute at Mount Sinai
We are using newly available structural information of opioid receptors in computer simulations to discover/design novel painkillers with reduced abuse liability and other adverse effects.
We are running massive computer simulations to find out how membrane protein complexes process cell signaling so that we can make drugs more specific and design more efficient medicines.