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Contributions to Team-Science Projects

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Through application and implementation of cutting-edge developments in theory and computer simulations, my lab contributes a level of molecular detail to biological and biomedical problems that is impossible or difficult to obtain experimentally. This information lays the foundation for novel experimental studies aimed at furthering our understanding of physiological functions, and at developing new therapeutic strategies.

 

Representative Publications

González-Maeso, J., Ang, R., Yuen,T, Chan, P., Weisstaub, N.V., López-Giménez, J., Zhou, M., Okawa, Y., Callado, L.F., Milligan, G., Gingrich, J.A., Filizola, M., Meana, J.J., Sealfon, S.C. “Identification of a Novel Serotonin/Glutamate Receptor Complex Implicated in Psychosis” Nature (2008) 452(7183):93-97.

 

Guo, W., Urizar, E., Kralikova,M., Mobarec, J.C., Shi, L., Filizola, M., Javitch, J.A. “Dopamine D2 Receptors Form Higher Order Oligomers at Physiological Expression Levels” The EMBO Journal, (2008) Sep 3;27(17):2293-304.

 

Fribourg, M., Moreno, J.L., Holloway, T., Provasi, D., Baki, L., Mahajan, R., Park, G., Adney, S.K., Hatcher, C., Eltit, J.M., Ruta, J.D., Albizu, L., Li, Z., Umali, A., Shim, J., Fabiato, A., MacKerell, A.D. Jr., Brezina, V., Sealfon, S.C., Filizola, M., Gonzalez-Maeso, J., Logothetis, D.E. “Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs” Cell (2011) 147 (5):1011-102.

 

Coudray, N., Valvo, S., Hu, M., Lasala, R., Kim, C., Vink, M., Zhou, M., Provasi, D., Filizola, M., Tao, J., Fang, J., Penczek, P.A., Ubarretxena-Belandia, I., Stokes, D.L. “Inward-Facing Conformation of the Zinc Transporter YiiP revealed by Cryo-electron Microscopy” Proc. Natl. Acad. Sci. USA (2013) 110(6):2140-2145.

 

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Project Details
Date 07 Jun 2015 Categories ALL Author admin