Contributions to Team-Science Projects

Through application and implementation of cutting-edge developments in theory and computer simulations, my lab contributes a level of molecular detail to biological and biomedical problems that is impossible or difficult to obtain experimentally. This information lays the foundation for novel experimental studies aimed at furthering our understanding of physiological functions, and at developing new therapeutic strategies.

Representative Publications

González-Maeso, J., Ang, R., Yuen,T, Chan, P., Weisstaub, N.V., López-Giménez, J., Zhou, M., Okawa, Y., Callado, L.F., Milligan, G., Gingrich, J.A., Filizola, M., Meana, J.J., Sealfon, S.C. “Identification of a Novel Serotonin/Glutamate Receptor Complex Implicated in Psychosis” Nature (2008) 452(7183):93-97.

Guo, W., Urizar, E., Kralikova,M., Mobarec, J.C., Shi, L., Filizola, M., Javitch, J.A. “Dopamine D2 Receptors Form Higher Order Oligomers at Physiological Expression Levels” The EMBO Journal, (2008) Sep 3;27(17):2293-304.

Fribourg, M., Moreno, J.L., Holloway, T., Provasi, D., Baki, L., Mahajan, R., Park, G., Adney, S.K., Hatcher, C., Eltit, J.M., Ruta, J.D., Albizu, L., Li, Z., Umali, A., Shim, J., Fabiato, A., MacKerell, A.D. Jr., Brezina, V., Sealfon, S.C., Filizola, M., Gonzalez-Maeso, J., Logothetis, D.E. “Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs” Cell (2011) 147 (5):1011-102.

Coudray, N., Valvo, S., Hu, M., Lasala, R., Kim, C., Vink, M., Zhou, M., Provasi, D., Filizola, M., Tao, J., Fang, J., Penczek, P.A., Ubarretxena-Belandia, I., Stokes, D.L. “Inward-Facing Conformation of the Zinc Transporter YiiP revealed by Cryo-electron Microscopy” Proc. Natl. Acad. Sci. USA (2013) 110(6):2140-2145.

Yano, H., Provasi, D., Sheng Cai, N., Filizola, M., Ferré, S., Javitch, J.A., “Development of novel biosensors to study receptor-mediated activation of Gs and Golf” (2017) Journal of Biological Chemistry Dec 8;292(49):19989-19998.

Hughes, T.E.T., Lodowski, D.T., Huynh, K.W., Yazici, A., Del Rosario, J., Kapoor, A., Bashak, S., Samanta, A., Han, X., Chakrapani, S., Zhou, Z.H., Filizola, M., Rohacs, T., Han, S., Moiseenkova-Bell, V.Y. “Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM ” (2018) Nature Structural & Molecular Biology, 25(1):53-60

Basak, S., Gicheru, Y., Kapoor, A., Mayer, M.L., Filizola, M. and Chakrapani, S. “Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor” (2019) Nature Communications 10(1): 3225

Nesic, D., Zhang, Y., Spasic, A., Li, J., Provasi, D., Filizola, M., Walz, T., and Coller, B.S. “Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex” (2020) Arteriosclerosis, Thrombosis, and Vascular Biology 40(3):624-637.

Basak, , Kumar, A. Ramsey, S., Gibbs, E., Kapoor, A., Filizola, M., Chakrapani, S. “High-resolution structures of multiple 5-HT_3AR-setron complexes reveal a novel mechanism of competitive inhibition” https://www.biorxiv.org/content/10.1101/2020.03.30.016154v1;  Elife (2020) 9:e57870.

Ahn, D., Provasi, D., Duc, N.M., Xu, J., Salas-Estrada, L., Spasic,, Yun, M.W., Kang, J., Gim, D., Lee, J., Du, Y., Filizola, M., Chung, K.Y. ^“Gαs slow conformational transition upon GTP binding and a novel Gαs regulator” bioRxiv (2022) doi: https://doi.org/10.1101/2022.10.10.511514;  (2023); iScience Apr 8;26(5):106603.